Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Correlation of Genotypic Susceptibility Testing and PZase Activity Assay
| PZase Activity | PZAR Isolates | Total | |||||||
|---|---|---|---|---|---|---|---|---|---|
| No Mutation | Mutants | ||||||||
| WT Genes | pncA | Rv2044c | rpsA | panD | Rv2783c | clpC1 | |||
| UFR | pncA | ||||||||
| No. of strains | 26 | 11 | 216 | 2 | 7 | 4 | 3 | – | 269 |
| PZase negative | 9 | 7 | 211 | 2 | – | – | – | – | 229 |
| PZase positive | 17 | 4 | 5 | – | 7 | 4 | 3 | – | 40 |
Note: PZAS strains (179/448) were observed with positive PZase activity.
Abbreviations: PZase, pyrazinamidase; UFR, upstream flanking region of pncA.
