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. 2020 Jan 22;12:511–522. doi: 10.2147/CMAR.S234735

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© 2020 Du et al.

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Cosmc disruption-mediated aberrant O-glycosylation inhibits cellular growth in vitro. (A) A RTCA assay was performed to determine the cell growth curves. MCF7 and T47D cell numbers were analyzed by RTCA at different time points up to 160 hrs. Data were presented as the means±SD from four replicated wells. (_*** P < 0.001). Both Tn-positive cells had decreased cell proliferation rate relative to the control Tn-negative cells. (B) Colony formation assay was performed in MCF7 and T47D cells. The results showed that both Tn-positive MCF7 and T47D cells formed fewer colonies than the control Tn-negative cells.