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. 2020 Jan 22;12:511–522. doi: 10.2147/CMAR.S234735

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© 2020 Du et al.

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Cosmc disruption delays tumor growth in vivo. (A) Effects of Cosmc disruption on tumor growth and proliferation in a Balb/c nude mouse model. Tn-positive MCF7 and T47D cells as well as the corresponding Tn-negative cells were subcutaneously injected into mice. Six mice were used for each group. Images of the excised tumors were shown. (B) The volume of tumors was measured at different time points in 21 days (_*** P < 0.001). (C) Tumor weight of Tn-positive MCF7 and T47D cell tumors in nude mice compared with control cell tumors (_*** P < 0.001). (D) Cell proliferation of tumors was evaluated by immunohistochemical staining of Ki67, and representative images were shown. The results showed that the size and weight of Tn-positive xenotransplants were reduced compared with Tn-negative xenotransplants. Besides, the number of Ki67-positive cells were fewer in mice treated with Tn-positive cells than in mice treated with Tn-negative cells.