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. Author manuscript; available in PMC: 2021 Jan 9.
Published in final edited form as: Cell. 2019 Dec 19;180(1):122–134.e10. doi: 10.1016/j.cell.2019.11.041

Figure 6. Structure of the Pore and the Ion Selectivity Filter.

Figure 6.

(A) The open ion permeation path shown in magenta surface calculated by MOLE2. DI and DIII PM with Asp373 and Lys1421 shown in sticks (Left panel), DII and DIV PM with Glu901 and Ala1713 shown in sticks (Right panel). DEKA: Asp373-Glu901-Lys1421-Ala1713.

(B) Top view of the rNaV1.5C SF with electron density shown in grey mesh contoured at 3 σ.

(C) SF comparison of NaV1.5c and activated NavAb (PDB,3RVY) shown in grey.

(D) Side view comparing the SF of rNaV1.5c and activated NavAb (PDB,3RVY).

(E) The charge delocalization complex of Lys1421. Lys1421 side chain interacts with adjacent backbone carbonyl group of Thr1419, Thr1711 and Thr1712, which are indicated by “(O)”. Magenta surface represents the ion permeation pathway inside the SF.