Figure 7.

Effects of donepezil on the memory deficits in the CaMKIIα‐tTA/A53T α‐syn dTg mice. (A) The CFC test was performed to evaluate associative learning of 12‐month‐old CaMKIIα‐tTA sTg and CaMKIIα‐tTA/A53T dTg mice. The percentage of freezing behavior was analyzed during the conditioning and retention phases. Vehicle or donepezil (1 mg/kg) was orally administered 2 hours prior to both the conditioning and retention phases. (B) The Y‐maze task was performed to evaluate spatial working memory of 12‐month‐old CaMKIIα‐tTA sTg and CaMKIIα‐tTA/A53T dTg mice. The percentage of alternations was measured. Vehicle or donepezil (1 mg/kg) was orally administered 2 hours prior to the test. Data are presented as the mean + SEM (n = 10); statistical significance between the vehicle‐treated CaMKIIα‐tTA sTg and CaMKIIα‐tTA/A53T α‐syn dTg mice was determined using Student's t‐test or Aspin‐Welch test (*P ≤ .05; **P ≤ .01). Significant differences between vehicle‐ and donepezil‐treated CaMKIIα‐tTA/A53T α‐syn dTg mice were determined by Student's t‐test or Aspin‐Welch test (^# P ≤ .05)