Comparison 1. Bronchial thermoplasty versus control.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 AQLQ final scores at 12 months of follow‐up	3	429	Mean Difference (IV, Random, 95% CI)	0.28 [0.07, 0.50]
1.1 Bronchial thermoplasty versus medical management	2	141	Mean Difference (IV, Random, 95% CI)	0.44 [0.10, 0.79]
1.2 Bronchial thermoplasty versus sham bronchoscopies	1	288	Mean Difference (IV, Random, 95% CI)	0.18 [‐0.09, 0.45]
2 ACQ final scores at 12 months of follow‐up	3	429	Mean Difference (IV, Random, 95% CI)	‐0.15 [‐0.40, 0.10]
2.1 Bronchial thermoplasty versus medical management	2	141	Mean Difference (IV, Random, 95% CI)	‐0.32 [‐0.63, ‐0.02]
2.2 Bronchial thermoplasty versus sham bronchoscopies	1	288	Mean Difference (IV, Random, 95% CI)	‐0.01 [‐0.23, 0.21]
3 Participants admitted to hospital because of respiratory adverse events (treatment period)	3	429	Risk Ratio (M‐H, Random, 95% CI)	3.50 [1.26, 9.68]
4 Participants admitted to hospital because of respiratory adverse events (post‐treatment period)	3	429	Risk Ratio (M‐H, Random, 95% CI)	1.12 [0.44, 2.85]
5 Use of rescue medication at 12 months of follow‐up (short‐acting bronchodilator puffs per week)	3	429	Mean Difference (IV, Random, 95% CI)	‐0.68 [‐3.63, 2.28]
5.1 Bronchial thermoplasty versus medical management	2	141	Mean Difference (IV, Random, 95% CI)	‐2.65 [‐11.24, 5.95]
5.2 Bronchial thermoplasty versus sham bronchoscopies	1	288	Mean Difference (IV, Random, 95% CI)	‐0.10 [‐3.38, 3.18]