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. 2019 Dec 26;161(1):bqz039. doi: 10.1210/endocr/bqz039

Figure 2.

Figure 2.

Uterine specific knock out of Atg16L1 impairs fertility. A) Diagram of the Atg16L1 cKO mutation. B) Expression of Atg16L1 is decreased in the uterus of Atg16L1 cKO virgin mice (n = 6 Control, 7 Atg16L1 cKO). C) Live birth rate, D) Number of litters, E) Litter size, and F) Total number of pups produced by control and Atg16L1 cKO mice over a 6-month period reveals compromised fertility in Atg16L1 mice (n = 5 Controls, 6 Atg16L1 cKO). G) Time to first litter as measured by plug date to delivery date is extended in Atg16L1 cKO mice; *P < 0.05, **P < 0.01, ***P < 0.001. ****P < 0.0001.