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Potential mechanism by which the PR target IRS2 promotes decidualization. During decidualization, PR induces IRS2 expression. IRS2 acts as an adaptor to insulin receptor, leading to downstream activation of MAPK and PI3K/AKT pathways, and increased expression of decidualization markers and glucose transporters. These GLUTs transport glucose into the cell to meet the increased metabolic demands of HESC decidualization, a critical step during pregnancy.
