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. Author manuscript; available in PMC: 2020 Jan 28.
Published in final edited form as: J Med Chem. 2020 Jan 7;63(2):656–675. doi: 10.1021/acs.jmedchem.9b01608

Figure 3.

Figure 3.

X-ray co-crystal structure of 16 bound to the WDR5 WIN-site (side-view, PDB ID: 6UCS). (A) Key H-bond (red dashed lines) and π−π stacking interaction residues of WDR5 that interact with 16. (B) Overlay of 13 (green sticks) and 16 (yellow sticks).