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. Author manuscript; available in PMC: 2020 Jan 28.
Published in final edited form as: J Med Chem. 2020 Jan 7;63(2):656–675. doi: 10.1021/acs.jmedchem.9b01608

Figure 4.

Figure 4.

Compound 16 displaced MLL1 from the WRAD protein complex. Endogenous immunoprecipitation (IP) using anti-WDR5 antibody or control IgG in MV4:11 cells treated for 4 h with DMSO or 1 μM 16. IP’ed material and whole cell lysates were probed with MLL1, RBBP5 and WDR5 antibodies.