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. Author manuscript; available in PMC: 2020 Jan 28.
Published in final edited form as: J Med Chem. 2020 Jan 7;63(2):656–675. doi: 10.1021/acs.jmedchem.9b01608

Figure 6.

Figure 6.

Compound 16 treatment induced p53 and p21 protein levels and apoptosis. (A) Western blot, showing the effects of DMSO or compound 16 (0.01 – 3.0 μM) on p53 and p21 protein levels in MV4:11 cells at 24h and 48h post treatment. GAPDH is a loading control. (B) Western blot, showing the effects of DMSO or compound 16 (0.3 μM) on p53 and p21 protein levels in MV4:11 cells in time course. GAPDH is a loading control. (C) Caspase 3/7 induction by compound 16 at 4, 24, 48, and 72 h time points in MV4:11 and Molm13 cells. (D) Cell cycle analysis of MV4:11 cells, showing 4-fold increased SubG1 cells by compound 16 treatment for 48 hours compared to DMSO control.