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. Author manuscript; available in PMC: 2020 Jan 28.
Published in final edited form as: J Med Chem. 2020 Jan 7;63(2):656–675. doi: 10.1021/acs.jmedchem.9b01608

Figure 7.

Figure 7.

Compound 16 displaces MYC from chromatin at WDR5-displaced genes. MYC or IgG control ChIP at three representative genes, SNHG15 (E-box locus), RPS24 and RPL35, at which 16 displaces WDR5 (as shown in Figure 5A). in MV4:11 cells. MYC or IgG control ChIPs were performed in MV4:11 cells after 4 h treatment with 0.1% DMSO or 600 nM 16. The SNHG15 gene body locus serves as a negative control for MYC binding. n = 3.