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. Author manuscript; available in PMC: 2020 Jan 28.
Published in final edited form as: J Med Chem. 2020 Jan 7;63(2):656–675. doi: 10.1021/acs.jmedchem.9b01608

Table 3.

Anti-proliferative Activity of Compound 16 in MYC-driven Cancers.

Compnd Cell line GI50 (μM)a
CHP-134 Ramos Raji Daudi SW620 SW480
1 2.7 ± 0.8 7.1 ± 1.4 16 ± 2.2 6.8 ± 4.0 6.5 ± 3.4 >29
16 0.26 ± 0.08 0.49 ± 0.24 1.2 ± 0.1 0.58 ± 0.26 3.2 ± 1.2 >22
a

Cell proliferation GI50 values represent average of three to five independent replicate determinations ± the standard deviation.