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. Author manuscript; available in PMC: 2020 Aug 13.
Published in final edited form as: Adv Drug Deliv Rev. 2019 Aug 13;144:90–111. doi: 10.1016/j.addr.2019.08.004

Fig. 3.

Fig. 3.

Possible endosomal escape of nanoparticles.

(A) Interaction of nanoparticles with endosomal membrane can destabilize the endosomal membrane, resulting to endosomal escape of the nanoparticles. (B) Nanoparticles including amines can rupture endosomes by osmotic pressure. (C) Nanoparticles designed to swell in acidic environment can burst endosomes and release their cargos to cytosol. Redrawn from [15].