Table 1.
Structures of GPCRs complexed with the G proteins or G protein mimics
| GPCR | G protein or mimetic nanobody | PDB ID (resolution) | Method | Reference |
|---|---|---|---|---|
| Opsin | C-terminal peptide of Gα transducin | 3DQB (3.2Å) | X-ray | (Scheerer et al., 2008) |
| β2AR | Gs and nanobody Nb35 | 3SN6 (3.2Å) | X-ray | (Rasmussen, DeVree, et al., 2011) |
| β2AR | Nanobody Nb80 | 3P0G (3.5Å) | X-ray | (Rasmussen, Choi, et al., 2011) |
| M2 | Nanobody Nb9–8 | 4MQS (3.5Å) | X-ray | (Kruse et al., 2013) |
| β2AR | Nanobody Nb6B9 | 4LDE (2.7Å), 4LDL (3.1Å), 4LDO (3.2Å) | X-ray | (Ring et al., 2013) |
| μOR | Nanobody Nb39 | 5C1M (2.1Å) | X-ray | (Huang et al., 2015) |
| A2AAR | Mini-Gs | 5G53 (3.4Å) | X-ray | (Carpenter et al., 2016) |
| GLP-1R | Gs | 5VAI (4.1Å) | Cryo-EM | (Zhang et al., 2017) |
| Calcitonin receptor | Gs | 5UZ7 (4.1Å) | Cryo-EM | (Liang et al., 2017) |
| Rhodopsin | Arrestin | 5W0P (3.0Å) | X-ray | (Zhou et al., 2017) |
| GLP1 | Gs | 6B3J (3.3Å) | Cryo-EM | (Liang et al., 2018) |
| KOR | Nanobody Nb39 | 6B73 (3.1Å) | X-ray | (Che et al., 2018) |
| μOR | Gi | 6DDE (3.5Å), 6DDF (3.5Å) | Cryo-EM | (Koehl et al., 2018) |
| A1AR | Gi | 6D9H (3.6Å) | Cryo-EM | (Draper-Joyce et al., 2018) |
| A2AAR | Gs and nanobody Nb35 | 6GDG (4.1Å) | Cryo-EM | (García-Nafría, Lee, et al., 2018) |
| Rhodopsin | Gi | 6CMO (4.5Å) | Cryo-EM | (Kang et al., 2018) |
| 5-HT1B | Go | 6G79 (3.8Å) | Cryo-EM | (García-Nafría, Nehmé, et al., 2018) |