Date	Event	Description
29 July 2009	New search has been performed	Literature search was updated. No new RCTs were identified. The lead author questions whether there will be any new trials in the foreseeable future. If there are no new trials identified in two years, we may consider marking this review as one that will no longer be updated. We will re‐assess it then.
28 May 2008	Amended	Converted to new review format.
24 October 2006	New citation required but conclusions have not changed	The additional RCT was published by Mathews et al in 1987. No other trials were identified. The addition of this study did not substantially alter the review's main results or conclusions. However, results are now presented in two sections, one for the three studies that examined prolotherapy injections alone compared to control injections and one for the two studies that examined prolotherapy injections combined with spinal manipulation, exercise, and other co‐interventions with control injections.
24 October 2006	New search has been performed	Review updated Since it had been over 3 years since the original review was published, an update was performed. Authors The primary author for the update is Simon Dagenais from the Children's Hospital of Eastern Ontario Research Institute, the University of Ottawa, and CAM Research Institute. Simon is a scientist with research experience related to prolotherapy. The secondary author is Michael Yelland, the primary author on the original review. Search strategy The original search strategy was modified since it was brought to the author's attention that an additional randomized controlled trial related to prolotherapy for chronic low back pain had not been identified in the original review.