Hellerstein 1994.

Methods	Randomised: medication bottles randomly assigned using a random numbers chart. The person who conducted this schemme was not involved in patient recruitment or treatment. Blindness: open label trial Duration: 3 months, with follow up at 5 months Design: 2 parallel groups, patients unable to tolerate a 12 week trial of one medication because of side effects were crossed over to the other medication Analysis: non intention‐to‐treat
Participants	Diagnosis: double depression (DSM‐III‐R) Age: mean 38 years Sex: 78% females Number: 18 Setting: outpatients History: 50% reported onset of illness in childhood (age lower than 13) and 6 as teenagers
Interventions	1. Fluoxetine (n=8); mean dose 40.8 mg/day 2. Trazodone (n=10); mean dose 300 mg/day
Outcomes	USED: responders (50% or greater decrease from initial HAM‐D score and score 1 or 2 on item 2 of CGI); HAM‐D scores; dropouts OUTCOMES UNABLE TO USE: SCL‐58 scores
Notes	Patients were extracted from a larger pool of 38 subjects (see Rosenthal 1992).
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Low risk	A ‐ Adequate