Table 2.
KEGG pathways enriched with differentially methylated genes in humans and rats*.
| Term | Genes | Fold-enrichment | FDR |
|---|---|---|---|
| Human | |||
| hsa00053:Ascorbate and aldarate metabolism | UGT1A7, UGT1A10, UGT1A6, UGT1A9, UGT1A8, UGT1A3, UGT1A5, UGT1A4, UGT2A2, UGT2A1, UGT1A1 | 4.7235 | 0.0006 |
| hsa04390:Hippo signaling pathway | WNT5A, PRKCZ, MOB1A, APC2, GDF6, WNT3A, GDF5, GLI2, LLGL1, TCF7L1, LOC400927-CSNK1E, FRMD6, PPP2R2B, PPP2R2C, DLG2, AXIN1, WNT10A, DVL3, TEAD3, PATJ, WWTR1, YWHAE, CTNNA2, DVL1, WNT9A, PARD6G, BMP7, PPP2R2A, BMP6 | 2.2267 | 0.0010 |
| hsa05200:Pathways in cancer | FGF6, FGF18, GNA11, WNT3A, ADCY6, LPAR3, LPAR2, FGF12, GLI2, SHH, FLT3LG, AKT1, CUL2, RARA, PRKACA, GNG7, WNT10A, CTBP1, RET, CTBP2, BCR, BRAF, FGF22, FGF21, DAPK1, CTNNA2, CCDC6, GNB2, JUN, PDGFRA, PIAS2, GNAS, WNT9A, ITGA2B, DCC, WNT5A, GNAI2, APC2, GNAI1, BCL2L1, TCF7L1, RAC3, PLEKHG5, LAMB1, TRAF4, AXIN1, FH, PIK3R2, DVL3, EPAS1, VHL, DVL1, LAMA1, ADCY9, NTRK1, ABL1, CRK | 1.6816 | 0.0012 |
| hsa00040:Pentose and glucuronate interconversions | UGT1A7, UGT1A10, UGT1A6, UGT1A9, CRYL1, UGT1A8, UGT1A3, UGT1A5, UGT1A4, UGT2A2, UGT2A1, UGT1A1 | 3.8647 | 0.0019 |
| hsa04611:Platelet activation | PRKCZ, TBXAS1, GNAI2, GNAI1, ADCY6, ARHGAP35, PRKG1, ITPR2, AKT1, VWF, PTGIR, GP6, ADCY9, P2RX1, MAPK12, COL27A1, TBXA2R, PRKACA, GNAS, FCGR2A, MYLK, PIK3R2, ITGA2B | 2.0512 | 0.0198 |
| hsa04010:MAPK signaling pathway | FGF6, FGF18, IL1R1, MKNK2, FGF12, AKT1, MAP3K6, MAP3K5, HSPA2, RAC3, PRKACA, RAPGEF2, CACNA2D1, BRAF, TAOK1, CACNG8, CACNG6, TAOK3, CACNA1I, FGF22, CACNG3, FGF21, CDC25B, RPS6KA5, RASGRF2, MAPK12, RPS6KA2, JUN, NTRK1, PDGFRA, CACNA1H, MAPK8IP3, CACNA1C, MAP3K13, CRK, CACNA1A, CACNA1B | 1.6823 | 0.0254 |
| hsa00860:Porphyrin and chlorophyll metabolism | UGT1A7, UGT1A10, UGT1A6, UGT1A9, UGT1A8, UGT1A3, UGT1A5, UGT1A4, UGT2A2, UGT2A1, UGT1A1 | 3.0365 | 0.0315 |
| hsa04713:Circadian entrainment | GNAI2, GNAI1, ADCY6, GRIN1, CACNA1I, GRIN2A, GRIA3, PRKG1, RPS6KA5, ADCY9, GNB2, RYR1, CACNA1H, PER1, GNAS, PRKACA, CACNA1C, GNG7 | 2.1968 | 0.0358 |
| hsa04530:Tight junction | SHROOM1, PRKCZ, OCLN, EPB41, GNAI2, GNAI1, PATJ, AMOTL1, LLGL1, CLDN14, CTNNA2, AKT1, PRKCQ, EXOC3, MYH14, PARD6G, TJP3, PPP2R2B, YES1, PPP2R2C, JAM3, MYH10, PPP2R2A | 1.9464 | 0.0389 |
| hsa00830:Retinol metabolism | GNAI2, GNAI1, ADCY6, GRIK4, GRIN1, GRIN2A, GRIA3, GRIN3A, SHANK2, ITPR2, GRM4, GLUL, ADCY9, GNB2, SLC1A7, GNAS, PRKACA, CACNA1C, CACNA1A, GNG7 | 2.7725 | 0.0404 |
| hsa04724:Glutamatergic synapse | UGT1A7, UGT1A10, UGT1A6, UGT1A9, UGT1A8, UGT1A3, UGT1A5, UGT1A4, UGT2A2, UGT2A1, UGT1A1 | 4.0579 | 0.0476 |
| Rat | |||
| rno04390:Hippo signaling pathway | Fzd9, Apc2, Gdf6, Tgfbr2, Tgfb3, Ppp1cc, Tcf7l1, Llgl1, Wnt7b, Crb1, Csnk1e, Dlg4, Wnt11, Bmp7, Axin2, Myc, Bmp6 | 3.5721 | 0.0002 |
| rno05200:Pathways in cancer | Fgfr2, Ppard, Apc2, Fgf14, Tgfb3, Fgf12, Tcf7l1, Tpm3, Gli1, Rasgrp1, Pax8, Prkaca, Axin2, Myc, Csf2ra, Traf3, Gng7, Fzd9, Map2k1, Tgfbr2, Hgf, Mecom, Dapk3, Vegfb, Wnt7b, Gnb2, Wnt11, Ptch1, Lamc1 | 2.3425 | 0.0005 |
| rno04010:MAPK signaling pathway | Fgfr2, Fgfr4, Cacna2d1, Map2k1, Fgf14, Cacna1i, Tgfbr2, Tgfb3, Fgf12, Mecom, Cacna2d2, Arrb2, Rasgrp1, Mapt, Ntrk2, Cacna1g, Prkaca, Myc, Cacna1a, Map2k6 | 2.4825 | 0.0053 |
| rno04810:Regulation of actin cytoskeleton | Fgfr2, Fgfr4, Apc2, Limk2, Map2k1, Fgf14, Wasf2, Nckap1l, Actn1, Pip5k1c, Fgf12, Itgb3, Ppp1cc, Src, Arpc1a, Ezr, Scin | 2.5070 | 0.0149 |
| rno04550:Signaling pathways regulating pluripotency of stem cells | Fgfr2, Fzd9, Fgfr4, Hnf1a, Tbx3, Apc2, Map2k1, Wnt7b, Pou5f1, Wnt11, Jak3, Axin2, Myc | 2.9852 | 0.0165 |
| rno05217:Basal cell carcinoma | Fzd9, Wnt7b, Apc2, Ptch1, Wnt11, Axin2, Tcf7l1, Gli1 | 4.6762 | 0.0183 |
*Bold text indicates differentially methylated genes in common between humans and rats in the same pathways