Table 1.

Summary of the most successful recombinant protein vaccines for LF reported in the last 10 years

Recombinant vaccine candidates	Percent Protection	Animal model used	References
Monovalent vaccine
TGA	30%	Jirds	[24]
TPX	43%	Jirds	[24]
GST	61%	Jirds	[25]
HSP12.6	58%	Mice	[54]
TSP	60%	Mice	[52]
TPP	71%	Mastomys coucha	[26]
DIM-1	50%	Mastomys coucha	[27]
Troponin 1	65%	Mice	[59]
Heavy chain myosin	84%	Mice	[57]
ALT-2 with Tuftsin	65%	Mice	[58]
FAR binding proteins	68%	Jirds	[28]
Calponin	42%	Mastomys coucha	[29]
Cocktail vaccine
TGA+TPX	74%	Jirds	[24]
ALT-2+TPX	80%	Mice	[51]
TRX+TPX	71%	Mastomys coucha	[30]
Myosin+ TPP	70%	Jirds	[32]
iPGM + TPP	70%	Jirds	[32]
VAL-1+ALT-2	77-80%	Jirds	[33]
Bivalent vaccine
HSP12.6+ALT-2	90%	Mice	[46]
HSP12.6+TSP	80%	Mice	[46]
TSP+ALT-2	82%	Mice	[46]
Bm-103, Bm-RAL-2	61%	Jirds	[28]
Multivalent vaccine
Multi antigen peptide (MAP)	63%	Jirds	[31]
Multiepitope	75%	Mastomys coucha	[35]
HAT	94%	Mice	[46]
Chimeric multistage filarial epitope protein (FEP)	70%	Jirds	[60]
HAT	45%	Rhesus macaque	[37]
HAXT	88%	Mice	[61]
HAXT	57%	Rhesus macaque	[38]