Table 1.
Associations of clinical cardiovascular risk factors with findings of brain abnormalities from structural cranial MRI in elderly American Indians
| Any infarct vs. no infarct | Lacunar infarct vs. no infarct | Non-lacunar infarct only vs. no infarct | Hemorrhage vs. none | WMH grade 3+ vs. WMH grades 1–2 | Sulcal grade 3+ vs. sulcal grades 1–2 | Ventricle grade 3+ vs. ventricle grades 1–2 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PR (95% CI) | p value | PR (95% CI) p value | PR (95% CI) | p value | PR (95% CI) | p value | PR (95% CI) | p value | PR (95% CI) | p value | PR (95% CI) | p value | ||
| Hypertension | 1.59 (1.20–2.10) |
0.001* | 1.67 (1.16–2.40) |
0.006* | 1.71 (1.01–2.90) |
0.046 | 0.61 (0.32–1.15) |
0.12 | 1.27 (1.01–1.60) |
0.04 | 1.07 (0.96–1.19) |
0.23 | 1.18 (1.04–1.33) |
0.011* |
| Diabetes | 1.23 (1.00–1.51) |
0.045 | 1.18 (0.91–1.53) |
0.21 | 1.52 (1.01–2.30) |
0.045 | 0.97 (0.55–1.71) |
0.91 | 1.14 (0.95–1.37) |
0.16 | 1.19 (1.08–1.31) |
0.001* | 1.27 (1.16–1.40) |
<0.001* |
| High LDL | 1.04 (0.84–1.28) |
0.75 | 1.01 (0.77–1.33) |
0.93 | 1.17 (0.75–1.83) |
0.49 | 1.24 (0.66–2.33) |
0.51 | 0.97 (0.79–1.18) |
0.74 | 1.02 (0.91–1.13) |
0.75 | 1.10 (0.99–1.21) |
0.08 |
Models adjusted for age, sex, site, income, education, smoking, alcohol, and BMI.
*
Denotes statistical significance after false discovery rate based correction for multiple comparisons.
MRI, magnetic resonance imaging; WMH, white matter hyperintensities; PR, prevalence ratio; LDL, low-density lipoprotein.