Table 2.
Secondary associations of clinical cardiovascular measures with findings of brain abnormalities from structural cranial MRI in elderly American Indians
| Any infarct vs. no infarct | Lacunar infarct vs. no infarct | Non-lacunar infarct only vs. no infarct | Hemorrhage vs. none | WMH grade 3+ vs. WMH grades 1–2 | Sulcal grade 3+ vs. sulcal grades 1–2 | Ventricle grade 3+ vs. ventricle grades 1–2 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PR (95% CI) | p value | PR (95% CI) | p value | PR (95% CI) | p value | PR (95% CI) | p value | PR (95% CI) | p value | PR (95% CI) | p value | PR (95% CI) | p value | |
| Fasting glucose, mg/dL | 1.00 (0.99–1.00) |
0.47 | 1.00 (0.99–1.00 |
0.79 | 1.00 (0.99–1.01) |
0.30 | 1.00 (0.99–1.01) |
0.33 | 1.00 (0.99–1.00) |
0.16 | 1.00 (0.99–1.00) |
0.23 | 1.001 (1.001–1.002) |
0.002 |
| SBP, mm Hg | 1.01 (1.00–1.01) |
0.003 | 1.00 (1.00–1.01) |
0.14 | 1.01 (1.01–1.02) |
0.001 | 1.00 (0.99–1.01) |
0.81 | 1.00 (0.99–1.01) |
0.10 | 1.00 (0.99–1.00) |
0.35 | 1.002 (1.000–1.004) |
0.04 |
| DBP, mm Hg | 1.00 (0.99–1.01) |
0.51 | 1.00 (0.99–1.02) |
0.58 | 1.01 (0.99–1.03) |
0.55 | 0.99 (0.97–1.02) |
0.70 | 1.01 (0.99–1.02) |
0.08 | 1.00 (0.99–1.01) |
0.42 | 1.00 (0.99–1.01) |
0.52 |
| LDL, mg/dL | 1.00 (0.99–1.00) |
0.33 | 1.00 (0.99–1.00) |
0.08 | 1.00 (0.99–1.01) |
0.71 | 1.00 (0.99–1.01) |
0.98 | 1.00 (0.99–1.00) |
0.06 | 0.99 (0.99–1.00) |
0.28 | 0.99 (0.99–1.00) |
0.27 |
Models adjusted for age, sex, site, income, education, smoking, alcohol, and BMI.
MRI, magnetic resonance imaging; WMH, white matter hyperintensities; PR, prevalence ratio; SBP, systolic blood pressure; DBP, diastolic blood pressure; LDL, low-density lipoprotein.