. Author manuscript; available in PMC: 2020 Jan 28.

Published in final edited form as: Neuroepidemiology. 2019 Jan 24;52(3-4):173–180. doi: 10.1159/000496343

Table 3.

Associations of clinical cardiovascular risk factors with estimated brain volumes from structural cranial MRI in elderly American Indians

	Hippocampal volume, per cm³		WMH volume, per cm³		Brain volume, per cm³
	β (95% CI)	p value	β (95% CI)	p value	β (95% CI)	p value
Hypertension	0.06 (−0.10 to 0.23)	0.45	1.32 (0.30 to 2.34)	0.01^*	0.27 (−9.85 to 10.39)	0.96
Diabetes	−0.07 (−0.21 to 0.06)	0.28	0.47 (-0.39 to 1.34)	0.28	−16.04 (−23.61 to −8.48)	<0.001^*
High LDL	0.08 (−0.05 to 0.21)	0.22	0.22 (-1.11 to 0.68)	0.64	−5.64 (−13.64 to 2.36)	0.17

Models adjusted for age, sex, site, income, education, smoking, alcohol BMI, and IC volume.

Statistical significance after false discovery rate based correction for multiple comparisons.

MRI, magnetic resonance imaging; WMH, white matter hyperintensities; LDL, low-density lipoprotein.