. Author manuscript; available in PMC: 2020 Jan 28.

Published in final edited form as: Neuroepidemiology. 2019 Jan 24;52(3-4):173–180. doi: 10.1159/000496343

Table 4.

Secondary associations of clinical cardiovascular measures with estimated brain volumes from structural cranial MRI in elderly American Indians

	Hippocampal volume, per cm³		WMH volume, per cm³		Brain volume, per cm³
	β (95% CI)	p value	β (95% CI)	p value	β (95% CI)	p value
Fasting glucose, mg/dL	−0.008 (−0.002 to 0.001)	0.22	0.002 (−0.01 to 0.01)	0.58	−0.04 (−0.12 to 0.04)	0.30
SBP, mm Hg	−0.004 (−0.007 to −0.001)	0.02	0.03 (0.01 to 0.06)	0.006	−0.08 (−0.25 to 0.10)	0.39
DBP, mm Hg	−0.001 (−0.008 to 0.005)	0.67	0.05 (0.01 to 0.10)	0.01	−0.03 (−0.40 to 0.34)	0.87
LDL, mg/dL	−0.0004 (−0.002 to 0.001)	0.68	−0.01 (−0.02 to 0.005)	0.22	0.08 (−0.03 to 0.19)	0.14

Models adjusted for age, sex, site, income, education, smoking, alcohol BMI, and IC volume

MRI, magnetic resonance imaging; WMH, white matter hyperintensities; SBP, systolic blood pressure; DBP, diastolic blood pressure; LDL, low-density lipoprotein.