Table 2. Seropositivity and seroconversion in plasma from hand, foot and mouth disease patients infected with EV-A71, CVA6, CVA10, and CVA16 viruses, Vietnam*.
| Virus | Immunity status | Virus, no. (%) samples |
|||
|---|---|---|---|---|---|
| CVA6 | CVA10 | CVA16 | EV-A71 | ||
| CVA6 | Seropositivity | ||||
| At enrollment | 2 (7) | 10 (33) | 5 (17) | 2 (7) | |
| At follow-up | 30 (100) | 9 (30) | 9 (30) | 3 (10) | |
| p value | <0.001 | 1.0 | 0.36 | 1.0 | |
|
|
Seroconversion |
28 (93) |
1 (3) |
7 (23) |
2 (7) |
| CVA10 | Seropositivity | ||||
| At enrollment | 4 (13) | 9 (30) | 3 (10) | 3 (10) | |
| At follow-up | 6 (20) | 29 (97) | 4 (13) | 5 (17) | |
| p value | 0.73 | <0.001 | 1.0 | 0.71 | |
|
|
Seroconversion |
4 (13) |
25 (83) |
3 (10) |
2 (7) |
| CVA16 | Seropositivity | ||||
| At enrollment | 7 (23) | 10 (33) | 8 (27) | 5 (17) | |
| At follow-up | 9 (30) | 11 (37) | 30 (100) | 7 (23) | |
| p value | 0.77 | 1.0 | <0.001 | 0.75 | |
|
|
Seroconversion |
3 (10) |
2 (7) |
23 (77) |
2 (7) |
| EV-A71 | Seropositivity | ||||
| At enrollment | 5 (17) | 17 (57) | 6 (20) | 18 (60) | |
| At follow-up | 7 (23) | 14 (47) | 8 (27) | 30 (100) | |
| p value | 0.75 | 0.61 | 0.76 | <0.001 | |
| Seroconversion | 4 (13) | 1 (3) | 3 (10) | 17 (57) | |
*n = 30 for each virus. p values reflect the results of statistical analysis comparing the seropositive rates between the 2 time points (enrollment and follow-up) of the corresponding enterovirus serotypes. CV, coxsackievirus; EV, enterovirus.