Table 3. Geometric mean titers of neutralizing antibodies against enteroviruses in study of patients with hand, foot and mouth disease, Vietnam*.
| Virus | Samples | Geometric mean titer (95% CI) of neutralizing antibodies |
|||
|---|---|---|---|---|---|
| CVA6 | CVA10 | CVA16 | EV-A71 | ||
| CVA6 |
Enrollment | 4.9 (3.6–6.7) | 13.3 (6.8–26.1) | 6.9 (4.3–11.3) | 5.0 (3.6–7.0) |
| Follow-up | 151.4 (113.0–202.8) | 13.0 (6.4–26.2) | 10.8 (5.6–20.8) | 6.0 (3.8–9.7) | |
| p value |
<0.001 |
0.83 |
0.021 |
0.50 |
|
| CVA10 |
Enrollment | 6.2 (3.9–9.7) | 10.1 (5.7–17.7) | 5.3 (3.8–7.2) | 5.9 (3.8–9.7) |
| Follow-up | 8.7 (4.8–16.1) | 245.5 (181.1–332.7) | 6.3 (4.0–10.1) | 7.6 (4.3–13.8) | |
| p value |
0.063 |
<0.001 |
0.098 |
0.50 |
|
| CVA16 |
Enrollment | 9.0 (5.0–16.0) | 13.6 (6.9–26.7) | 10.5 (5.7–18.6) | 7.4 (4.3–12.9) |
| Follow-up | 10.3 (5.7–18.7) | 14.6 (7.5–28.5) | 141.2 (104.547–191.0) | 9.8 (5.1–18.7) | |
| p value |
0.25 |
1.0 |
<0.001 |
0.098 |
|
| EV-A71 | Enrollment | 6.6 (4.2–10.4) | 23.2 (11.5–46.7) | 7.6 (4.4–13.0) | 37.7 (17.9–79.4) |
| Follow-up | 9.4 (5.3–16.7) | 18.8 (10.0–35.4) | 10.1 (5.4–18.7) | 295.1 (260.6–334.2) | |
| p value | 0.073 | 0.31 | 0.25 | <0.001 | |
*p values reflect the results of statistical analysis comparing the geometric mean titers between the 2 time points (enrollment and follow-up) of the corresponding enterovirus serotypes. CV, coxsackievirus; EV, enterovirus; HFMD, hand, foot and mouth disease.