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. 2020 Jan 28;9:e50670. doi: 10.7554/eLife.50670

Figure 7. Model for GLI transcriptional repression.

(A) Summary of enhancer status at HH-responsive GBRs. (B) In the absence of HH, GLI repressors bind to enhancers for HH target genes, limiting their accessibility and, directly or indirectly, recruiting an HDAC complex that de-acetylates Histone H3K27, inactivating the enhancer. In the presence of HH signaling, GLI de-repression and loss of associated HDAC activity result in increased accessibility, the accumulation of H3K27ac and gene transcription. (C) Schematic showing tissue-restricted activity of HH-responsive GBRs within HH-responsive gene expression domains. (D) Possible roles for Stable GBRs in HH transcriptional regulation.

Figure 7.

Figure 7—figure supplement 1. Summary of enhancer status at Stable GBRs.

Figure 7—figure supplement 1.

Normalized fold enrichment of the indicated enhancer marks at all Stable GBRs.