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. Author manuscript; available in PMC: 2020 Jan 28.
Published in final edited form as: J Invest Dermatol. 2018 Dec 10;139(6):1339–1348. doi: 10.1016/j.jid.2018.11.028

Figure 5. The combination of IgG2a(TA99) and TA99-mTNF kills most of the neoplastic mass and boosts infiltration of NK cells and macrophages.

Figure 5

A, H&E analysis of tumor sections 24 hours after administration of IgG2a(TA99) and TA99-mTNF. Scale bar = 2.5 mm. Detection of activated caspase-3 (B), Asialo GM1 on NK cells (C) and F4/80 on macrophages (D) by immunofluorescence (green, Alexa Fluor 488) in B16F10 tumor sections 24 hours after combination treatment with IgG2a(TA99) and TA99-mTNF. Blood vessels stained stained with anti-CD31 (red, Alexa Fluor 594). Magnification 20x, scale bar = 100 μm