Table 2.
Genes associated with meningiomas
| Gene | Full name | Locus | Product | Function |
|---|---|---|---|---|
| NF2 | Neurofibromin 2 | 22q12.2 | Merlin | Tumor suppressor |
| Maintain cell shape by linkage cell membrane proteins to cytoskeleton | ||||
| TRAF7 | TNF receptor-associated factor 7 | 16p13.3 | TNF receptor-associated factor 7 | E3 ubiquitin ligase |
| Interaction with MAPK pathway | ||||
| KLF4 | Kruppel-like factor 4 | 9p31 | Kruppel-like factor 4 | Transcription factor |
| Induction of pluripotency | ||||
| AKT1 | v-Akt murine thymoma viral oncogene homolog 1 | 14q32.33 | AKT1 kinase (serine/threonine protein kinase) | Oncogene |
| Regulate cell growth and division, control apoptosis | ||||
| SMO | Smoothened, frizzled class receptor | 7p32.1 | Smoothened, G protein-coupled receptor | Activation of hedgehog pathway |
| Cell growth, proliferation | ||||
| PIK3CA | Phosphadidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha | 3q26.32 | Catalytic subunit of kinase, PI3K | Activation of PI3K/AKT pathway |
| POLR2A | RNA polymerase II subunit A | 17p13.1 | RNA polymerase II subunit A | Formation of preinitiation complex for transcription |
| FAK | Focal adhesion kinase | 8q24.3 | Protein tyrosine kinase2 | Cytoplasmic tyrosine kinase |
| Cellular proliferation and motility | ||||
| BAP1 | BRCA1-associated protein 1 | 3p21.1 | Ubiquitin carboxyl-terminal hydrolase 1 | Deubiquitinase, tumor suppressor |
| Control cell growth, division and cell death | ||||
| SMARCB1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 | 22q11.23 | Subunit of SWI/SNF complex | Tumor suppressor |
| Regulate gene activity by chromatin remodeling | ||||
| SMARCE1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 | 17q21.2 | Subunit of SWI/SNF complex | Tumor suppressor |
| Regulate gene activity by chromatin remodeling | ||||
| BRAF V600E | B-Raf proto-oncogene | 7q34 | Serine/threonine kinase | Oncogene |
| Involved in MAPK pathway | ||||
| NOTCH2 | Notch receptor 2 | 1p12 | Notch2 (notch receptor family) | Transmembrane receptor |
| Involved in Notch signaling pathway | ||||
| CHEK2 | Checkpoint kinase2 | 22q12.1 | Checkpoint kinase 2 (CHK2) | Tumor suppressor |
| Regulate cell division | ||||
| PTEN | Phosphatase and tensin homolog | 10q23.31 | Phosphatidylinositol-3,4,5-triphosphate 3-phosphatase | Tumor suppressor |
| Negative regulation of mTOR pathway | ||||
| CDKN2A | Cyclin-dependent kinase inhibitor 2A | 9p21.3 | p16(INK4A) | Tumor suppressor |
| p14(ARF) | Cell cycle progression (G1/S phase) | |||
| CDKN2B | Cyclin-dependent kinase inhibitor 2B | 9p21.3 | p15(INK4B) | Tumor suppressor |
| Cell cycle progression (G1/S phase) | ||||
| DMD | Dystrophin | Xp21.1 | Dystrophin | Cytoskeletal construction, cell proliferation and motility |
| TERTp | Telomerase reverse transcriptase | 5p15.33 | Telomerase reverse transcriptase | Maintain telomere end |