Table 2.
Distribution of cases according to the amounts of colorectal cancer-associated microbes in colorectal carcinoma tissue and the incidence of anastomotic leakage after resection of colorectal carcinoma
| The amount of microbes in colorectal carcinoma tissue | All patients (n = 256) |
Patients without anastomotic leak (n = 227) |
Patients with anastomotic leak (n = 29) |
Ptrenda |
|---|---|---|---|---|
| Fusobacterium nucleatum | 0.45 | |||
| Negative | 116 (46%) | 104 (46%) | 12 (41%) | |
| Low | 70 (27%) | 63 (28%) | 7 (24%) | |
| High | 70 (27%) | 60 (26%) | 10 (35%) | |
| pks-positive Escherichia coli | 0.13 | |||
| Negative | 162 (64%) | 148 (65%) | 14 (48%) | |
| Low | 47 (18%) | 39 (17%) | 8 (28%) | |
| High | 47 (18%) | 40 (18%) | 7 (24%) | |
| Enterococcus faecalis | 0.99 | |||
| Negative | 63 (25%) | 55 (24%) | 8 (28%) | |
| Low | 95 (37%) | 86 (38%) | 9 (31%) | |
| High | 98 (38%) | 86 (38%) | 12 (41%) | |
| Bifidobacterium genus | 0.002 | |||
| Negative | 167 (65%) | 155 (68%) | 12 (41%) | |
| Low | 44 (17%) | 38 (17%) | 6 (21%) | |
| High | 45 (18%) | 34 (15%) | 11 (38%) |
a
Ptrend value was calculated by the linear trend test across the ordinal (negative, low, and high) categories of the amount of the intestinal microbes as a continuous variable in univariable logistic regression model for the incidence of anastomotic leakage (a dichotomous outcome variable). All statistical tests were two-sided at α level of 0.005, considering the multiple comparisons and the consequent false positives.