Figure 3. Kennedy Pathway does not contribute to the Lrh-1 regulation of mitochondrial activities.
A. Diagram of Kennedy and PEMT pathways. B. Expression of Lrh-1 and its target genes was measured in Chka KD or Pcyt1a KD C3A/HepG2 cells. C. Expression of Pgc1α mRNA was measured in Chka KD or Pcyt1a KD C3A/HepG2 cells. D. Expression of beta-oxidation related genes was measured in Chka KD or Pcyt1a KD C3A/HepG2 cells. E. Mitochondrial DNA copy number was measured in Chka or Pcyt1a KD C3A/HepG2 cells.