Table 3.
Mean absolute error (MAE) and percentage within 20% of actual dose in the overall test set of the Caribbean Hispanic cohort.
| Models | MAE (mg/week) | Within 20% |
|---|---|---|
| RPART | 6.27 (4.16-8.38) | 72.22 |
| MARS | 8.52 (5.92-11.12) | 55.56 |
| RFR | 4.73 (3.24-6.21) | 80.56 |
| ANN | 9.73 (6.53-12.93) | 58.33 |
| SVR# | 6.86 (4.75-8.97) | 61.11 |
| iBK1 | 6.78 (4.41-9.15) | 66.67 |
| iBK2 | 6.30 (3.88-8.71) | 69.44 |
| iBK3 | 6.15 (3.72-8.57) | 72.22 |
| REPT# | 9.87 (6.62-13.12) | 47.22 |
#best prediction model does not include common variants in VKORC1 (rs9923231), CYP2C9 (rs1799853), CYP4F2 (rs2108622) and NQO1 (rs1800566).
Data are expressed as mean (95% CI) or percentage. MAE, mean absolute error; multivariate adaptive regression splines (MARS), artificial neural networks (ANN), random forest regression (RFR), support vector regression (SVR), K-nearest neighbor for K from 1 to 3 (iBK1, iBK2, iBK3), recursive partitioning (RPART) and reduces error pruning tree classifier (REPT).