Table 4.
Mean absolute error and mean percentage within 20% of actual dose stratified by therapeutic warfarin dose requirements (i.e., sensitives, resistant and normal) in the test set of the Caribbean Hispanic cohort.
| Models | Normal | Sensitive | Resistant | |||
|---|---|---|---|---|---|---|
| MAE (mg/week) | Within 20% | MAE (mg/week) | Within 20% | MAE (mg/week) | Within 20% | |
| RPART | 4.17 (2.60-5.73) | 88.00 | 9.83 (3.53-16.12) | 37.50 | 14.28 (7.19-21.37) | 33.33 |
| MARS | 6.98 (4.44-9.52) | 68.00 | 11.44 (6.55-16.33)# | 25.00 | 7.22 (2.11-12.33)# | 66.67 |
| RFR | 2.91(2.18-3.64)# | 100.00 | 7.17 (3.48-10.86)# | 50.00 | 13.45 (7.41-19.48) | 33.33 |
| ANN | 8.03 (5.01-11.05) | 68.00 | 10.32 (1.49-19.15) | 50.00 | 16.75 (10.87-22.63)# | 0.00 |
| SVR | 5.67 (3.82-7.53)# | 68.00 | 4.79 (1.21-8.36) | 75.00 | 19.44 (15.83-23.05) | 0.00 |
| iBK1 | 3.62 (2.01-5.24) | 88.00 | 12.81 (6.15-19.48)# | 25.00 | 12.83 (2.48-23.18) | 33.33 |
| iBK2 | 3.75 (1.94-5.55) | 88.00 | 9.33 (2.17-16.49)# | 37.50 | 7.58 (2.33-17.50) | 66.67 |
| iBK3 | 3.83 (2.01-5.64) | 88.00 | 9.33 (2.17-16.49)# | 37.50 | 7.58 (2.33-17.50) | 66.67 |
| REPT | 6.89 (4.68-9.09)# | 56.00 | 12.30 (2.60-22.01)# | 37.50 | 15.08 (2.67-27.50) | 66.67 |
#best prediction model does not include common variants in VKORC1 (rs9923231), CYP2C9 (rs1799853), CYP4F2 (rs2108622) and NQO1 (rs1800566).
Data are expressed as mean (95% CI) or percentage. MAE: mean absolute error; multivariate adaptive regression splines (MARS), artificial neural networks (ANN), random forest regression (RFR), support vector regression (SVR), K-nearest neighbor for K from 1 to 3 (iBK1, iBK2, iBK3), recursive partitioning (RPART) and reduces error pruning tree classifier (REPT).