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. 2020 Jan 22;9:460. doi: 10.3389/fcimb.2019.00460

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Copyright © 2020 Wu, Wei, Jiang, Li, Zou and Peng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Protein–protein interaction (PPI) network of host dependency genes. Among the 1,183 proteins, 428 (36.12%) of host dependency genes were enriched in a large PPI network, with 1,136 edges. Seven PPI clusters were evident in the network. The biggest one is a cluster of E3 ubiquitin-protein ligases containing 25 proteins (in green), including TRIM63, UBE3D, HECTD1, ARIH2, ZNF645, and CBLB, was observed as one of the main hubs. The second one is a cluster of 25 olfactory receptor proteins (in red) with RTP1 in the center. A cluster of 12 USP proteins (in medium slate blue) was also found protruding. Detailed information on these seven PPI clusters is shown in Table S6.