Table 1.
Expression profile of the developmental cues involved in tooth development
| Expression stages | Signal molecules | Expression sites |
|---|---|---|
| Initiation stage | BMP4, FGF8, FGF9, WNT7b, SHH | Dental epithelium |
| FGF10 | Dental epithelium Dental mesenchyme | |
| Early bud stage | FGF8, FGF9, FGF15, FGF20 | Dental epithelium |
| BMP4 | Dental mesenchyme | |
| Late bud stage | BMP4, FGF3, FGF4, FGF9, FGF15, FGF20 | Primary enamel knot |
| FGF3, FGF10, FGF18 | Dental mesenchyme | |
| FGF16, FGF17 | Cervical loop mesenchyme | |
| Initiation and bud stages | WNT10a, WNT10b | Dental epithelium |
| Bud and cap stages | SHH | Enamel knot |
| Cap stage | BMP2, BMP7 | Dental epithelium Dental mesenchyme |
| WNT10a, WNT10b | Enamel knot | |
| WNT4, WNT6 | Dental epithelium | |
| WNT5a | Dental mesenchyme | |
| Early bell stage | BMP2, BMP7 | Dental papilla |
| Bell stage | FGF4, FGF20 | Secondary enamel knots |
| FGF9, FGF16 | Ameloblasts | |
| SHH | Inner enamel epithelium Stratum intermedium cells | |
| Late bell stage | BMP2 | Odontoblasts |
| BMP7 | Odontoblasts Ameloblasts | |
| FGF3 | Dental papilla | |
| FGF10 | Odontoblasts |