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. 2020 Jan 28;10:1346. doi: 10.1038/s41598-020-58309-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Exploratory behavior in Elevated Plus Maze and Open Field tests. Exploratory behavior is presented as the percentage of time spent in the open arms of the Elevated Plus Maze (A) or in the center zone in the Open Field (B) tests conducted during weeks 20–22. Box plots represent the median values for each group with interquartile ranges and error bars indicating the minimum and maximum. **Represents p < 0.01 and *represents p < 0.05 (Mann Whitney U-test). For sedentary mice n = 14 and for running mice n = 14.