Figure 2.

Microbial regulation of circadian physiology. Diurnal oscillation of microbiota synchronizes the whole body systems through the microbiota-derived signals and metabolites. Dysbiosis induced by various factors, such as diet and jet lag, alters the expression of several circadian genes, resulting in a detrimental impact on the host health. clock shape circle, endogenous clock of different tissues; red thunder, disruption in diurnal gene expression; circle with wave, schematic representation of diurnal oscillation; circle with line, schematic representation of flat/not diurnal level.