Table 1.
Salient features of dermatophytosis due to terbinafine resistant Trichophyton species.
| Patient ID | Organism | NCCPF No./ITS accession No/SE gene accession No. | Antifungal exposure | Relapse | MIC(mg/L) Terbinafine | Amino acid substitution | Nucleotide substitution |
|---|---|---|---|---|---|---|---|
| 27/17 | T. mentagrophytes complex | 800052/MH517546/MH618757 | Terbinafine | No | 2 | F397L | 1189TTC → CTC |
| 50/17 | T. mentagrophytes complex | 800053/MH517547/MH618758 | Terbinafine | No | 2 | F397L | 1189TTC → CTC |
| 60a/17 | T. mentagrophytes complex | 800060/MH517548/MH618759 | No | Yes | 2 | F397L | 1189TTC → CTC |
| 60b/17 | T. mentagrophytes complex | 800061/MH517549/MH618760 | Terbinafine | Yes | 2 | F397L | 1189TTC → CTC |
| 69/17 | T. mentagrophytes complex | 800054/MH517550/MH618761 | No | Yes | 8 | F397L | 1189TTC → CTC |
| 91/17 | T. mentagrophytes complex | 800066/MH517551/MH618762 | Terbinafine | No | 8 | F397L | 1189TTC → TTA |
| 100/17 | T. mentagrophytes complex | 800059/MH517552/MH618763 | No | No | 8 | F397L | 1189TTC → CTC |
| 110b/17 | T. mentagrophytes complex | 800065/MH517553/MH618764 | Terbinafine | Yes | 16 | F397L | 1189TTC → TTA |
| 134b/17 | T. mentagrophytes complex | 800057/MH517554/MH618765 | Luliconazole | No | 8 | F397L | 1189TTC → CTC |
| 134c/17 | T. mentagrophytes complex | 800058/MH517555/MH618766 | Terbinafine | No | 8 | F397L | 1189TTC → CTC |
| 135/17 | T. mentagrophytes complex | 800056/MH517556/MH618767 | No | No | 4 | F397L | 1189TTC → CTC |
| 54/17 | T. mentagrophytes complex | 800063/MH517557/MH618768 | No | No | 2 | F397L | 1189TTC → TTA |
| 138/17 | T. mentagrophytes complex | 800055/MH517558/MH618769 | No | No | 16 | F397L | 1189TTC → CTC |
| 176/17 | T. mentagrophytes complex | 800064/MH517559/MH618770 | No | Yes | 8 | F397L | 1189TTC → TTA |
| 200/17 | T. mentagrophytes complex | 800062/MH517560/MH618771 | No | Yes | 8 | F397L | 1189TTC → TTA |