Table 2.

Pharmacokinetic parameters of scutellarin, rosuvastatin, and rosuvastatin under combination treatment (n = 6, data presented as mean ± standard deviation).

Pharmacokinetic parameters	Rosuvastatin treatment (10 mg/kg)	Combination treatment: rosuvastatin + scutellarin	P value
Half life (t1/2, h)	4.47 ± 1.31	4.76 ± 1.53	0.731
Tmax(h)	2.05 ± 0.660	2.16 ± 0.582	0.765
Cmax(ng/mL)	545 ± 143	846 ± 202*	0.0153
Clearance rate(ml/h/·kg)	501 ± 69.0	307 ± 42.1**	0.000
AUC0-last (ng·/h·ml)	2.94 × 103 ± 854	4.74 × 103 ± 1.22 × 103*	0.0161
AUC0-∞ (ng·/h·ml)	2.96 × 103 ± 896	4.76 × 103 ± 1.23 × 103*	0.0223

Compared groups: rosuvastatin treatment vs. combination treatment (rosuvastatin + scutellarin). *Indicates difference compared with the rosuvastatin alone group (P < 0.05), **indicates great difference compared with the rosuvastatin alone group (P < 0.01).