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. 2020 Jan 28;10:1349. doi: 10.1038/s41598-020-58452-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Apelin protected PUs formation in cutaneous I/R injury mouse model. (A) The size of the wound area after I/R injury in normal C57BL/6 mice treated with subcutaneous injection of apelin (10 ng/mice) or phosphate-buffered saline as a control. The size of the ulcer in control mice at 4 days after reperfusion was assigned a value of 100% (vehicle: n = 9, apelin: n = 10, for each time point and group). (B) Representative images of the wound after cutaneous I/R in control or apelin treated mice at 0, 4, 8, and 12 days after reperfusion. (C) Comparison of mRNA levels of apelin expression during wound healing in I/R site between control and apelin-treated mice at 4, 12 and 48 hours after I/R injury. n = 5. All values represent mean ± SEM. **P < 0.01, *P < 0.05.