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. 2020 Jan 28;11:567. doi: 10.1038/s41467-019-14131-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Illustration of the process of nucleation and growth of Pt NPs. b The varying sizes of Pt NPs in patient blood at 0.5 h after cisplatin treatment (top), in the urine 0.5 h after treatment (middle) and in the blood 24 h after treatment (bottom). The right panels show a higher magnification. c The concentration of Pt NPs in patient blood after cisplatin chemotherapy over a 30 d period after treatment. d Illustration of the glomerular filtration of different sized Pt NPs; Pt NPs <6 nm more easily traverse the GBM than Pt NPs >6 nm.