Table 2.
Maternal lipid concentrations and gestational change in lipid concentrations by BMI group.
| Overall, N = 575 | Preconception BMI <25 kg/m2, N = 335 | Preconception BMI ≥25 kg/m2, N = 240 | P value | |
|---|---|---|---|---|
| Preconception lipid concentrationa (mg/dL) | ||||
| Total cholesterol | 165.4 (28.6) | 161.4 (27.3) | 170.9 (29.5) | <0.0001 |
| LDL-C | 90.7 (25.2) | 87.0 (22.8) | 95.9 (27.5) | <0.0001 |
| HDL-C | 52.0 (12.3) | 55.2 (12.3) | 47.6 (10.7) | <0.0001 |
| Triglyceride | 114.1 (60.0) | 97.2 (41.8) | 137.8 (72.4) | <0.0001 |
| 28-week lipid concentrationb (mg/dL) | ||||
| Total cholesterol | 239.8 (41.7) | 243.3 (42.6) | 234.9 (39.9) | 0.020 |
| LDL-C | 130.7 (38.3) | 134.0 (38.4) | 126.1 (37.9) | 0.020 |
| HDL-C | 64.5 (15.0) | 66.3 (14.9) | 62.1 (15.0) | 0.002 |
| HDL-C at 20 weeksc (HDL-C peak) | 66.6 (14.9) | 69.0 (14.6) | 63.4 (14.7) | <0.0001 |
| Triglyceride | 223.2 (72.8) | 215.7 (71.2) | 233.3 (74.5) | 0.006 |
| Change in lipid concentration, preconception to 28 weeks gestation (mg/dL) | ||||
| Total cholesterol | 74.1 (38.4) | 81.7 (36.7) | 63.5 (38.2) | <0.0001 |
| LDL-C | 39.7 (34.7) | 46.8 (33.8) | 29.8 (33.5) | <0.0001 |
| HDL-C | 12.7 (11.4) | 11.1 (11.4) | 14.8 (11.1) | 0.0002 |
| HDL-C, 0 to 20 weeks (HDL-C peak) | 14.7 (10.8) | 13.8 (11.0) | 15.9 (10.4) | 0.027 |
| Triglyceride | 109.1 (67.1) | 118.3 (65.7) | 96.3 (67.0) | 0.0002 |
Maternal lipid concentrations at preconception, at 28 weeks gestation, and the calculated change in lipid concentration from preconception to 28 weeks are presented for the overall cohort and by BMI group (<25 v. ≥25 kg/m2), limited to n = 575 women with singleton birth between 22–43 weeks gestation and birthweight and maternal preconception BMI available. Mean (SD) presented for all lipids. P value for significant difference in lipid concentration or lipid change by BMI group (one-way ANOVA) is presented.
BMI, body mass index; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol.
aMissing lipid values, preconception: Total cholesterol and triglyceride, n = 9 overall, n = 4 BMI <25, n = 5 BMI ≥25; LDL-C, n = 16 overall, n = 7 BMI <25, n = 9 BMI ≥25; HDL-C, n = 13 overall, n = 7 BMI <25, n = 6 BMI ≥25;
bMissing lipid values, 28 weeks, for all lipids: n = 38 overall, n = 23 BMI <25, n = 15 BMI ≥25.
cMissing HDL-C values, 20 weeks: n = 36 overall, n = 23 BMI <25, n = 13 BMI ≥25.