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. 2020 Jan 28;11:550. doi: 10.1038/s41467-020-14312-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Schema of scRNA-seq analysis of iGBMs. b Uniform Manifold Approximation and Projection (UMAP) analysis of all sequenced samples. c Principal component analysis of all sequenced samples (the color code is same as in b). d The heatmap of GBM molecular subtype analysis based on average gene expression of individual cells in each sample for a manually curated gene list based on ref. ¹⁸.