Table 1. Overall survival median by PD-L1 22C3 assay cutoffs.
Trial | Overall survival (m, 95% CI) | FU (m) | ||
---|---|---|---|---|
TPS ≥50% | TPS 1–49% | TPS <1% | ||
KN-001 (tx naïve) | 35.4 (20.3–63.5) | 19.5 (10.7–26.3) | 60.0 | |
KN-024 | 30.0 (18.3–NR) | 25.2 | ||
KN-042 | 20.0 (15.4–24.9) | 13.4 (10.7–18.2) | 12.8 | |
KN-189 | NR (>20.4) | 21.8 (17.7–25.9) | 17.2 (13.8–22.8) | 18.7 |
CI, confidence interval; FU, median follow-up; KN, KEYNOTE; m, month(s); NR, not reached; PD-L1, programmed cell death ligand 1; TPS, tumor proportion score; tx, treatment.