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. 2020 Jan 22;10:1377. doi: 10.3389/fneur.2019.01377

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Copyright © 2020 Liebau, Schilp, Mugridge, Schön, Kather, Kammerer, Tillein, Braun and Plontke.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Dependence of perilymph dexamethasone concentration in the scala tympani of implanted animals with 0.1, 1, and 10% loaded dexamethasone silicone rods on time after implantation (mean and SD, n = 3 per sample point). A burst release phase lasting 1–7 days, depending on silicone drug loading, was followed by a steady state phase characterized by constant drug concentrations. (B) Dependence of cochlear tissue dexamethasone concentration of implanted animals with 0.1, 1, and 10% loaded dexamethasone silicone rods on time after implantation (mean and SD, n = 3 per sample point). The concentration time course in tissue drug concentrations reflected the temporal dynamic seen in the perilymph dexamethasone concentrations. Measured concentrations in tissue were 2,000 times lower than perilymph drug concentrations.