Table 1.
Infection parameters for single and mixed species infections of Plasmodium yoelii CU with Plasmodium vinckei DS, Plasmodium chabaudi AJ, and Plasmodium chabaudi ASED.
| Strain | PyCU | PvDS | PcAJ | PcASED | PyCU + PvDS | PyCU + PcAJ | PyCU + PcASED |
|---|---|---|---|---|---|---|---|
| RBC invasion preference | Reticulocytes | Normocytes | Normocytes and reticulocytes | Normocytes and reticulocytes | / | / | / |
| Peak Parasitaemia % (day pi) | 52.57 ± 1.89 (18–19, 25) | 36.44 ± 0.54 (6–7) |
63.85 ± 4.94 (7) |
59.91 ± 1.03 (6, 7) |
75.78 ± 1.72 (8, 10–11) | 59.96 ± 3.56 (7–8) | 64.32 ± 3.43 (7, 9) |
| Cumulative parasitaemia | 544.74 ± 80.00 | 127.94 ± 6.32 | 245.55 ± 14.83 | 190.21 ± 7.49 | 281.52 ± 26.66 | 218.39 ± 16.87 | 188.53 ± 9.45 |
| Mortality (day pi) | 0% | 0% | 40% (10, 13) | 40% (9, 10) | 100% (9, 11, 12) | 100% (9, 10) | 100% (9–11) |
| Max. weight loss, g (day pi) | 1.26 ± 0.44 (19–21, 27) | 2.49 ± 1.00 (8, 10) | 4.06 ± 0.54 (9–13) | 3.54 ± 0.38 (8, 9) | 4.26 ± 0.66 (8, 9–12) | 2.93 ± 0.30 (8–9) | 2.92 ± 0.18 (8, 10) |
| Min. RBC count, RBC/ml (day pi) | 1.61 × 109 ± 0.13 × 109 (21, 26, 28) | 3.61 × 109 ± 0.05 × 109 (8, 9) | 1.51 × 109 ± 0.21 × 109 (9) | 1.41 × 109 ± 0.13 × 109 (7, 8) | 1.60 × 109 ± 0.04 × 109 (8–11) | 1.65 × 109 ± 0.22 × 109 (8, 9) | 1.24 × 10 9 ± 0.08 × 109 (7, 8) |