Table 3.

Cisplatin unsuitability and borderline unsuitability criteria.

Unsuitable	Borderline unsuitable
Hypersensitivity to platinum	N/A
Pregnancy/lactation	N/A
Untreated chronic active hepatitis B or C	N/A
ECOG PS ≥ 3	ECOG PS ≥ 2
Preexisting renal dysfunction (CCR < 60 mL/min)	Any renal dysfunction and associated risk factors
Severe hearing impairment	Any hearing disorder and associated risk factors
Severe neurological disorders	Any neurological disorder (including peripheral sensory symptoms) and associated risk factors
Severe immunological condition (CD4-lymphocyte count <200/mm3, a detectable viral load, an acquired immunodeficiency syndrome)	Any immunological condition
Insufficient hydration	Poor hydration
Platelet count, < 100,000/mm3; neutrophil count, < 1,500/mm; or hemoglobin <9 g/dL; despite optimization attempt	Preexisting hematologic condition, anemia
NYHA class III or IV congestive heart failure	NYHA class I or II congestive heart failure in the presence of a left ventricular ejection fraction of ≤50%
N/A	Preexisting gastrointestinal condition, history of motion sickness and pregnancy-induced vomiting
N/A	Diabetes
N/A	Biological age ≥70 years
N/A	Bone marrow disorders
N/A	Having received platinum agents in induction chemotherapy

CCR, creatinine clearance rate; ECOG PS, Eastern Cooperative Oncology Group performance status; N/A, not applicable; NYHA, New York Heart Association.