Figure 3.

Metabolic reprogramming of tissue macrophages in obesity. In obesity, tissue macrophages are exposed to an excessive and altered nutrient environment and receive a variety of danger signals from damaged parenchymal cells. This can rewire the metabolic programming of tissue macrophages, altering the activation state of these cells. Although these macrophages may exert protective functions as shielding and clearance of apoptotic cells, they can also release local and systemic mediators that can further exacerbate metabolic disease.