TABLE 1.

Anesthetics effects on the functional connectivity in rodents.

Anesthetics	Doses	Comparison	Effects	Studies	Species
Isoflurane	1%	vs. the awake state	Preserve interhemispheric FC	Jonckers et al. (2014)	Mice
		vs. anesthetics	Cortical and thalamo-cortical FC preserved but disruption of striatal FC	Grandjean et al. (2014)
			Cortico-cortical FC preserved but disruption of thalamo-cortical FC	Bukhari et al. (2017)
	1–2%	Increasing doses	Disruption of interhemispheric FC with increasing doses	Bukhari et al. (2018)
	1.3%	vs. the awake state	Cortico-cortical and striatal FC increase	Paasonen et al. (2018)	Rats
Medetomidine	0.1 mg/kg	vs. anesthetics	Disruption of thalamo-cortical FC but pronounced striatal FC	Grandjean et al. (2014)	Mice
			Thalamo-cortical FC preserved but disruption cortico-cortical FC	Bukhari et al. (2017)	Mice
		vs. the awake state	Cortico-cortical FC decreased	Paasonen et al. (2018)	Rats
Med/iso	0.05 mg/kg; 0.5%	vs. anesthetics	Preserved FC	Grandjean et al. (2014)	Mice
				Bukhari et al. (2017)
	0.06 mg/kg; 0.5%	vs. the awake state	Thalamo-cortical and intra-subcortical FC decrease	Paasonen et al. (2018)	Rats
Urethane	2.5 g/kg	vs. the awake state	Disruption of interhemispheric FC	Jonckers et al. (2014)	Mice
	1.5 g/kg	vs. anesthetics	Cortical and thalamo-cortical FC preserved but disruption of striatal FC	Grandjean et al. (2014)
	1.25 g/kg	vs. the awake state	Replication of the awake state	Paasonen et al. (2018)	Rats
α-chloralose	120 mg/kg	vs. the awake state	Disruption of interhemispheric FC	Jonckers et al. (2014)	Mice
	60 mg/kg	vs. the awake state	Cortico-cortical FC suppression	Paasonen et al. (2018)	Rats

Review of five studies between 2014 and 2018.