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Ipragliflozin increased urine vasopressin and solute‐free water reabsorption in diabetic GK rats. Effect of ipragliflozin on serum osmolality (a), urine vasopressin (b), urine osmolality (c), osmolar clearance (d), solute‐free water reabsorption (e), and electrolyte‐free water clearance (f). Veh: normal diet (CE2, CLEA JAPAN Inc.); Ipra: normal diet containing ipragliflozin [100 mg/kg diet]. *p < .05 versus Veh. Values are expressed as means ± standard error; n = 8–11/group
