Figure 5.

The relationship between urinary glucose and Na⁺ excretion and urine vasopressin. Urinary glucose excretion was positively correlated with urine vasopressin (a). Urinary Na⁺ excretion tended to be correlated with urinary vasopressin (b). Urine vasopressin in ipragliflozin‐treated diabetic GK rats was significantly and positively correlated with solute‐free water reabsorption (c). In ipragliflozin‐treated diabetic GK rats, urinary glucose excretion was positively and significantly correlated with urine volume (d), and there was a positive trend relationship between urinary glucose excretion and serum Na⁺ (e). Urinary glucose excretion in ipragliflozin‐treated rats was not associated with fluid balance (f). Veh: normal diet (CE2, CLEA JAPAN Inc.); Ipra: normal diet containing ipragliflozin [100 mg/kg diet]. Values are expressed means ± standard error; n = 4–12/group